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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
APC
All Species:
19.09
Human Site:
S2174
Identified Species:
35
UniProt:
P25054
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P25054
NP_000029.2
2843
311646
S2174
I
L
K
P
G
E
K
S
T
L
E
T
K
K
I
Chimpanzee
Pan troglodytes
XP_001143509
2844
311637
S2175
I
L
K
P
G
E
K
S
T
L
E
T
K
K
I
Rhesus Macaque
Macaca mulatta
XP_001095216
2303
243755
R1641
C
I
S
S
A
L
P
R
R
R
P
P
V
S
G
Dog
Lupus familis
XP_536285
2273
247246
I1611
S
T
L
E
T
K
K
I
E
S
E
N
K
G
I
Cat
Felis silvestris
Mouse
Mus musculus
Q61315
2845
311071
S2174
I
L
K
P
G
E
K
S
T
L
E
A
K
K
I
Rat
Rattus norvegicus
P70478
2842
310514
S2174
I
L
K
P
G
E
K
S
T
L
E
A
K
K
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511806
2844
309621
S2175
I
L
K
P
G
E
K
S
T
L
E
S
K
K
V
Chicken
Gallus gallus
XP_001233411
2232
244958
E1570
T
L
E
S
K
K
V
E
S
E
S
K
G
I
K
Frog
Xenopus laevis
P70039
2829
310863
G2163
K
T
I
T
S
N
K
G
P
K
I
L
K
P
A
Zebra Danio
Brachydanio rerio
NP_001137312
2754
301074
D2084
R
Q
G
S
S
D
S
D
S
I
L
S
L
K
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477152
2417
261266
S1755
H
A
D
S
Y
S
G
S
S
G
G
L
N
F
Q
Honey Bee
Apis mellifera
XP_624558
2760
306907
K2098
N
T
L
N
E
S
N
K
T
N
E
I
T
E
E
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_783363
3212
346162
S2544
P
S
R
A
S
T
T
S
Q
S
S
V
S
K
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
35
74.2
N.A.
90.4
90.1
N.A.
86.7
67.1
75
68
N.A.
23.8
22.8
N.A.
29.1
Protein Similarity:
100
99.5
49.4
76.1
N.A.
94.2
94.3
N.A.
92.7
72.2
84
78.2
N.A.
41
42
N.A.
45.1
P-Site Identity:
100
100
0
26.6
N.A.
93.3
93.3
N.A.
86.6
6.6
13.3
6.6
N.A.
6.6
13.3
N.A.
13.3
P-Site Similarity:
100
100
6.6
33.3
N.A.
93.3
93.3
N.A.
100
26.6
13.3
33.3
N.A.
13.3
20
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
8
8
0
0
0
0
0
0
16
0
0
8
% A
% Cys:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
0
0
8
0
8
0
0
0
0
0
0
0
% D
% Glu:
0
0
8
8
8
39
0
8
8
8
54
0
0
8
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% F
% Gly:
0
0
8
0
39
0
8
8
0
8
8
0
8
8
8
% G
% His:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
39
8
8
0
0
0
0
8
0
8
8
8
0
8
39
% I
% Lys:
8
0
39
0
8
16
54
8
0
8
0
8
54
54
8
% K
% Leu:
0
47
16
0
0
8
0
0
0
39
8
16
8
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
0
8
0
8
8
0
0
8
0
8
8
0
0
% N
% Pro:
8
0
0
39
0
0
8
0
8
0
8
8
0
8
0
% P
% Gln:
0
8
0
0
0
0
0
0
8
0
0
0
0
0
16
% Q
% Arg:
8
0
8
0
0
0
0
8
8
8
0
0
0
0
0
% R
% Ser:
8
8
8
31
24
16
8
54
24
16
16
16
8
8
8
% S
% Thr:
8
24
0
8
8
8
8
0
47
0
0
16
8
0
0
% T
% Val:
0
0
0
0
0
0
8
0
0
0
0
8
8
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _